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SURPASS J-combo study comparing people with T2DM in a Japanese population with a high HbA1c on oral antihyperglycemic monotherapy on 5, 10, or 15 mg of once weekly tirzepatide for 52 weeks showed an improvement of glycemic and lipid control, weight loss and reduction in blood pressure [57]

Heres what you can expect the lab work to assess: Hemoglobin A1c (HbA1c): shows average blood sugar levels over 23 months [3] Cholesterol (HDL, LDL, triglycerides): establishes heart health baselines [4] TSH (thyroid-stimulating hormone): screens for thyroid issues that can affect weight or energy Creatinine and BUN: confirms kidney function is healthy [5] Complete blood count (CBC): flags infection, inflammation, or other systemic issues How often do you need labs

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For RCTs with zero events in any treatment of interest arms, we combined risk of stroke using a Cochran MantelHaenszel test with a continuity correction of 0.5